Active CREB1 Promotes a Malignant TGFβ2 Autocrine Loop in Glioblastoma
نویسندگان
چکیده
منابع مشابه
Active CREB1 promotes a malignant TGFβ2 autocrine loop in glioblastoma.
UNLABELLED In advanced cancer, including glioblastoma, the TGFβ pathway acts as an oncogenic factor. Some tumors exhibit aberrantly high TGFβ activity, and the mechanisms underlying this phenomenon are not well understood. We have observed that TGFβ can induce TGFβ2, generating an autocrine loop leading to aberrantly high levels of TGFβ2. We identified cAMP-responsive element-binding protein 1 ...
متن کاملActive CREB1 Promotes a Malignant TGFb2 Autocrine Loop in Glioblastoma
In advanced cancer, including glioblastoma, the TGFβ pathway acts as an oncogenic factor. Some tumors exhibit aberrantly high TGFβ activity, and the mechanisms underlying this phenomenon are not well understood. We have observed that TGFβ can induce TGFβ2, generating an autocrine loop leading to aberrantly high levels of TGFβ2. We identifi ed cAMP-responsive element–binding protein 1 (CREB1) as...
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ژورنال
عنوان ژورنال: Cancer Discovery
سال: 2014
ISSN: 2159-8274,2159-8290
DOI: 10.1158/2159-8290.cd-14-0275